Document Detail


Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer.
MedLine Citation:
PMID:  24734154     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Early screening for colorectal cancer (CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is an appealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design.
Authors:
Ganepola Ap Ganepola; Joel Nizin; John R Rutledge; David H Chang
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of gastrointestinal oncology     Volume:  6     ISSN:  1948-5204     ISO Abbreviation:  World J Gastrointest Oncol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-15     Completed Date:  2014-06-24     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  101532470     Medline TA:  World J Gastrointest Oncol     Country:  China    
Other Details:
Languages:  eng     Pagination:  83-97     Citation Subset:  -    
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