Document Detail

Use of bisphosphonates to treat severe idiopathic hypercalcaemia in a young Ragdoll cat.
MedLine Citation:
PMID:  21036642     Owner:  NLM     Status:  MEDLINE    
A 3-year-old Ragdoll cat was referred for investigation of polyuria, polydipsia, vomiting, weight loss and hypercalcaemia. Serum biochemical abnormalities included total and ionised hypercalcaemia and hypophosphataemia. Following clinical investigations a diagnosis of idiopathic hypercalcaemia was made. Because of the severity of the hypercalcaemia and the associated clinical signs, treatment for hypercalcaemia was commenced with pamidronate. Major electrolyte abnormalities were detected but, remarkably, were accompanied by minimal clinical signs. The cat was subsequently treated with oral alendronate and is clinically normal 15 months later. Reports of the use of bisphosphonates in cats are limited and close monitoring of patients is recommended.
Joanna L Whitney; Vanessa R D Barrs; Margaret R Wilkinson; Katherine A Briscoe; Julia A Beatty
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-10-30
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  13     ISSN:  1532-2750     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-04-04     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia.
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MeSH Terms
Alendronate / therapeutic use*
Bone Density Conservation Agents / therapeutic use*
Cat Diseases / drug therapy*
Diphosphonates / therapeutic use*
Follow-Up Studies
Hypercalcemia / drug therapy,  veterinary*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 40391-99-9/pamidronate; 66376-36-1/Alendronate

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