Document Detail

Use of biomarkers of collagen types I and III fibrosis metabolism to detect cardiovascular and renal disease in chimpanzees (Pan troglodytes).
MedLine Citation:
PMID:  20412692     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease is the leading cause of morbidity and mortality among captive chimpanzees. The most prevalent form of cardiovascular disease among chimpanzees is sudden cardiac death. Myocardial fibrosis was the only significant pathologic lesion observed in affected animals at necropsy. We previously showed an association between myocardial fibrosis and sudden cardiac death. The presumed pathogenesis was interstitial myocardial fibrosis that led to decreased myocardial contractility and interrupted signal propagation in the heart, leading to fibrillation and resulting in sudden cardiac death. In this pilot study, we assayed 5 biomarkers of collagen types I and III metabolism and fibrogenesis and studied their association with CVD in chimpanzees. The biomarker MMP1 did not crossreact in chimpanzee sera and could not be studied further. Two biomarkers (TIMP1 and PINP) and their difference showed no significant association with CVD in chimpanzees. The biomarkers ICTP and PIIINP were significantly increased in cases of CVD with concurrent renal disease. Furthermore, both biomarkers showed a significant trend to increase with disease severity. We conclude that ICTP and PIIINP warrant further study for antemortem detection of renal and myocardial fibrosis in chimpanzees.
John J Ely; Micah A Bishop; Michael L Lammey; Meg M Sleeper; Jörg M Steiner; D Rick Lee
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Comparative medicine     Volume:  60     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-30     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-8     Citation Subset:  IM    
Alamogordo Primate Facility, Charles River Consulting and Staffing Services, Holloman Airforce Base, New Mexico, USA.
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MeSH Terms
Ape Diseases / blood*,  metabolism,  pathology
Biological Markers / blood*
Cardiovascular Diseases / blood,  metabolism,  pathology,  veterinary*
Case-Control Studies
Collagen Type I / metabolism*
Collagen Type III / metabolism*
Fibrosis / blood,  metabolism,  pathology,  veterinary
Kidney Diseases / blood,  metabolism,  pathology,  veterinary*
Matrix Metalloproteinase 1 / blood
Pan troglodytes* / blood
Peptide Fragments / blood
Procollagen / blood
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Collagen Type III; 0/Peptide Fragments; 0/Procollagen; 0/procollagen Type III-N-terminal peptide; EC Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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