| Use of bifemelane hydrochloride in improving and maintaining the visual field of patients with glaucoma. | |
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MedLine Citation:
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PMID: 8851457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the change of visual fields in 40 patients with primary or secondary glaucoma. No limitations were placed on the type of angular glaucoma (ie, open or closed). The intraocular pressure of the patients had been controlled at < 20 mm Hg for 2 years before the study, and patients with normal-tension glaucoma also were included. We evaluated the effect of 48 months of treatment with bifemelane hydrochloride, 150 mg/d in three divided doses, on 20 patients with glaucoma. The control group included 20 glaucoma patients whose intraocular pressure had been controlled at < 20 mm Hg for 2 years before the study by the instillation or oral administration of an intraocular hypotensive agent. They had not received any oral agent, such as a cerebral circulation metabolism activator. Results showed that the visual field was improved in 14 (70%) of 20 patients who received bifemelane hydrochloride, whereas the visual field was improved in 4 (20%) of 20 patients in the control group. More patients in the bifemelane hydrochloride group had improved visual fields than in the control group; differences between groups were significant. In addition, an evaluation of the visual field with the use of the Kosaki and Inoue classification showed improvement in all patients in stages IIa to V. We conclude that this drug is useful for maintaining and improving the disturbed visual field of patients in whom the intraocular pressure can be maintained at < 20 mm Hg and in patients who can tolerate 150 mg/d in three separate doses. |
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Authors:
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T Shigemitsu; Y Majima |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 18 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1996 Jan-Feb |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 106-13 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Fujita Health University School of Medicine, Toyoake, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzhydryl Compounds / pharmacology, therapeutic use* Glaucoma / drug therapy* Humans Visual Fields / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 90293-01-9/bifemelane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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