Document Detail

Use of available dosage forms of cephalexin in clinical comparison with phenoxymethyl penicillin and benzathine penicillin in the treatment of streptococcal pharyngitis in children.
MedLine Citation:
PMID:  4157353     Owner:  NLM     Status:  MEDLINE    
The effectiveness of cephalexin, an oral cephalosporin using a dosage equivalent to available capsular dosage forms, was studied in relation to the effectiveness of phenoxymethyl penicillin and benzathine penicillin in the treatment of 128 patients with beta-hemolytic streptococcal pharyngitis, all but six of whom had group A streptococci isolated from throat cultures. Approximately one-half, 66 patients, received cephalexin for 10 days; 34 patients received phenoxymethyl penicillin for 10 days; and 28 patients had a single injection of benzathine penicillin. There were four treatment failures determined bacteriologically post-therapy, two in the cephalexin treatment group and one each in the oral penicillin and intramuscular penicillin groups. Similar cure rates of 96.7, 97.1, and 96.4% were computed for the respective treatment regimens. Whereas intramuscular benzathine penicillin remains the regimen of choice in most instances, cephalexin appeared to be as effective as oral penicillin in the elimination of group A streptococci from the pharynx when oral treatment was desired for streptococcal pharyngitis.
J M Matsen; O Torstenson; S E Siegel; H Bacaner
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  6     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1974 Oct 
Date Detail:
Created Date:  1993-11-24     Completed Date:  1993-11-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Bacteriological Techniques
Cephalexin / administration & dosage*,  adverse effects
Child, Preschool
Follow-Up Studies
Injections, Intramuscular
Microbial Sensitivity Tests
Penicillin G Benzathine / administration & dosage*
Penicillin V / administration & dosage*
Pharyngitis / drug therapy*,  microbiology
Streptococcal Infections / drug therapy*
Reg. No./Substance:
1538-09-6/Penicillin G Benzathine; 15686-71-2/Cephalexin; 87-08-1/Penicillin V; 9006-92-2/Antistreptolysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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