| Use of atropine in patients with submaximal heart rate during exercise myocardial perfusion SPECT. | |
| | |
MedLine Citation:
|
PMID: 12569331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Failure to reach 85% of maximal predicted heart rate (MPHR) during exercise may render a myocardial perfusion single photon emission computed tomography (MPS) study nondiagnostic for ischemia detection. Although commonly used to increase heart rate (HR) during dobutamine stress, the administration of atropine for patients failing to achieve 85% of MPHR during exercise performed for MPS is still infrequent. METHODS AND RESULTS: Patients undergoing dual-isotope MPS were considered candidates for the study when, during exercise treadmill testing, they had less than 85% of MPHR and were unable to continue because of fatigue, without an ischemic response. Forty-seven patients (aged 65.3 +/- 12.5 years, 78.7% men) received atropine (0.6-1.2 mg). Maximal HR achieved before and after atropine was 118.0 +/- 14.8 beats/min (76.3% +/- 6.2% of MPHR) and 146.4 +/- 12.6 beats/min (94.4% +/- 8.1% of MPHR), respectively (P < .001). Of patients, 44 (93.6%) reached at least 85% of MPHR after atropine and had diagnostic MPS studies. After atropine, arrhythmias occurred in 14 patients (29.8%) and other minor side effects in 1 (2.1%). CONCLUSIONS: Atropine allows patients initially failing to achieve 85% of MPHR during exercise to increase HR and have a diagnostic MPS study, without major complications. It may provide an alternative to pharmacologic stress for patients with a blunted HR response to exercise. |
| | |
Authors:
|
Andrea De Lorenzo; James Foerster; Maria G Sciammarella; Cathy Suey; Sean W Hayes; John D Friedman; Daniel S Berman |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 10 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 2003 Jan-Feb |
Date Detail:
|
Created Date: 2003-02-05 Completed Date: 2003-08-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
|
Department of Imaging (Division of Nuclear Medicine), Cedars-Sinai Medical Center, Los Angeles, Calif 90048, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Arrhythmias, Cardiac / etiology Atropine / adverse effects, diagnostic use*, pharmacology Exercise Test* Female Heart Rate / drug effects* Humans Male Middle Aged Myocardial Ischemia / radionuclide imaging* Parasympatholytics / adverse effects, diagnostic use*, pharmacology Radiopharmaceuticals / diagnostic use Technetium Tc 99m Sestamibi / diagnostic use Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed, Single-Photon / methods |
| Chemical | |
Reg. No./Substance:
|
0/Parasympatholytics; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential systolic and diastolic effects of beta-adrenergic stimulation in patients with severe l...
Next Document: Detection and reproducibility of mental stress-induced myocardial ischemia with Tc-99m sestamibi SPE...