| Use of aortic valvo-pumps placed in valve annulus for long-term left ventricular assist. | |
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MedLine Citation:
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PMID: 16340359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To provide better anatomical fit and physiologic adaptation, three aortic valvo-pumps with different dimensions were developed. Each pump has a rotor with an impeller and drive magnets and a stator consisting of a motor coil with iron core and an outflow guide vane. The devices had outer diameters of 21 mm, 23 mm, and 25 mm, respectively, and weighted 27 g, 31 g, and 40 g, respectively. Laboratory testing demonstrated that the rotating speed for maintaining a diastolic pressure of 80 mm Hg at zero flow rate should be 17500 rpm, 15000 rpm, and 12500 rpm, respectively; the largest flow at these same speeds will be 5 l/min, 7 l/min, and 10 l/min, respectively, with approximately 50 mm Hg pressure head increase. Therefore, these three pumps may meet the hemodynamic requirements of patients with body weights of 40-60 kg, 60-80 kg, and 80-100 kg. The first in vivo trial exhibited that the 25 mm valvo-pump can be sewn onto the aortic valve annulus of a 80 kg body weight pig without harm to adjacent organ functions. The devices occupy no additional anatomic space and deliver the blood directly from ventricle to the aorta, thus producing less physiologic disturbance to the natural circulation. Neither connecting conduits nor bypass circuits are necessary, thus eliminating the most dangerous sites of thrombosis in traditional left ventricular assist devices. |
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Authors:
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Kun-Xi Qian; Dongfang Wang; Stephen R Topaz; Wei-Min Ru; Pei Zeng; Hai-Yu Yuan; Hao Wang; Fang-Qung Wang; Zi-Gang Feng; Joseph B Zwischenberger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 51 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-03-02 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 736-8 Citation Subset: IM |
Affiliation:
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Jiangsu University Biomedical Engineering Institute, Zhenjiang, China. swyx@ujs.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Valve / surgery Biomedical Engineering Heart-Assist Devices* Humans Prosthesis Design Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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