Document Detail

Use of antipsychotics during pregnancy and breastfeeding.
MedLine Citation:
PMID:  23034313     Owner:  NLM     Status:  Publisher    
There is growing acceptance that pregnancy itself is not a protective factor against mental disorders. Indeed, some mental disorders such as psychotic and bipolar disorders may become worse during pregnancy and the immediate postpartum period. In pregnant women with a mental disorder that can be treated with antipsychotics, the known risks -teratogenic, obstetric, neonatal and those affecting the mother- indicate that, in general, the risk of the non-treated disorder is higher than that resulting from the use of antipsychotics and that the reduction in psychoticism improves the overall prognosis of these women. All the antipsychotics marketed in Spain are included in category C of the US Food and Drug Administration, with the exception of clozapine and piperazine, which are included in category B. The use of all of these drugs should be avoided during breast feeding as far as possible. The most reliable current recommendations indicate that optimal control of severe mental disorders should be maintained during pregnancy, the postpartum and subsequent periods. These recommendations also indicate that women with mental disorders must be considered as high risk and that both these women and their pregnancies should be constantly monitored. The currently available scientific information does not allow more than relatively secure individually-tailored recommendations to be made. When taking the decision of whether or not to treat with antipsychotics, the use of a risk-benefit relationship is crucial, with the participation of the woman's partner or legal representative, other physicians and even the clinical pharmacist if necessary.
José Manuel Bertolín Guillén; Enrique Soler Company
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-10-14
Journal Detail:
Title:  Revista de psiquiatria y salud mental     Volume:  2     ISSN:  1989-4600     ISO Abbreviation:  Rev Psiquiatr Salud Ment     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528851     Medline TA:  Rev Psiquiatr Salud Ment     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  138-145     Citation Subset:  -    
Copyright Information:
Copyright © 2009 Sociedad Española de Psiquiatría and Sociedad Española de Psiquiatría Biológica. Published by Elsevier Espana. All rights reserved.
Unidad de Hospitalización Psiquiátrica, Servicio de Psiquiatría, Departamento de Salud Valencia-Arnau de Vilanova, Agència Valenciana de Salut, Valencia, España. Electronic address:
Vernacular Title:
Uso de antipsicóticos durante el embarazo y la lactancia.
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