Document Detail


Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis.
MedLine Citation:
PMID:  23049226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ulcerative jejunoileitis is an uncommon clinical syndrome consisting of abdominal pain, weight loss associated with diarrhea, and multiple inflammatory ulcerations and strictures of the small bowel. Ulcerative jejunoileitis can complicate established celiac disease or develop in patients de novo. Increased levels of tumor necrosis factor-alpha (TNF-α) in the small intestine of patients with untreated celiac disease are associated with a role in the immune pathogenesis of this disorder. No specific therapy has been shown to change the course of ulcerative jejunoileitis. We report a case of severe ulcerative jejunoileitis previously unresponsive to traditional therapies, including high dose corticosteroids and cyclosporine. The patient had a dramatic resolution of symptoms and a complete normalization of endoscopic findings after anti-TNF-α monoclonal antibody, infliximab (Remicade(®)).
Authors:
Gulseren Seven; Adel Assaad; Thomas Biehl; Richard A Kozarek
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-05-03     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5135-7     Citation Subset:  IM    
Affiliation:
Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98101, United States.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use*
Enteritis / drug therapy*
Humans
Ileitis / drug therapy*
Jejunal Diseases / drug therapy*
Male
Middle Aged
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Ulcer / drug therapy*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Tumor Necrosis Factor-alpha; 0/infliximab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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