| Use of analytically defined estimates of aerosol respirable fraction to predict lung deposition patterns. | |
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MedLine Citation:
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PMID: 1488409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analytical estimates of the respirable fractions on inhaled pharmaceutical aerosols are obtained by inertial sampling techniques. The respirable fraction may be defined as that portion of the particle size distribution less than a designated diameter. The diameter size below which particles were considered respirable in these studies was 6.4 microns. In clinical practice, a variety of particle size distributions may be related to a single respirable fraction. Herein, three respirable fractions were each defined by six particle size distributions. The deposition patterns of aerosols exhibiting these particle size characteristics were examined in a mathematical model. The analytically defined respirable fractions were compared with predicted lung deposition values. Under clearly defined breathing conditions, there is a correlation between the nominal respirable fraction and deposition. However, it was concluded that the variations which occur in breathing parameters within patient populations may not allow a single analytically derived respirable fraction to be appropriate for all individual subjects. |
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Authors:
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T B Martonen; I Katz; K Fults; A J Hickey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pharmaceutical research Volume: 9 ISSN: 0724-8741 ISO Abbreviation: Pharm. Res. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-02-19 Completed Date: 1993-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1634-9 Citation Subset: IM |
Affiliation:
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Health Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols Humans Lung / metabolism* Models, Biological Particle Size Respiratory Function Tests Tidal Volume |
| Chemical | |
Reg. No./Substance:
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0/Aerosols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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