Document Detail

Use of amino acids as growth hormone-releasing agents by athletes.
MedLine Citation:
PMID:  12093449     Owner:  NLM     Status:  MEDLINE    
Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally. Many individuals consume amino acids before strength training workouts, believing this practice accentuates the exercise-induced GH release, thereby promoting greater gains in muscle mass and strength. The GH response to amino acid administration has a high degree of interindividual variability and may be altered by training status, sex, age, and diet. Although parenteral administration consistently leads to increased circulating GH concentration, oral doses that are great enough to induce significant GH release are likely to cause stomach discomfort and diarrhea. During exercise, intensity is a major determinant of GH release. Although one study showed that arginine infusion can heighten the GH response to exercise, no studies found that pre-exercise oral amino acid supplementation augments GH release. Further, no appropriately conducted scientific studies found that oral supplementation with amino acids, which are capable of inducing GH release, before strength training increases muscle mass and strength to a greater extent than strength training alone. The use of specific amino acids to stimulate GH release by athletes is not recommended.
Joseph A Chromiak; Jose Antonio
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  18     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-08-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  IM    
Department of Health, Physical Education, Recreation and Sport, Mississippi State University, PO Box 6186, Mississippi State, MS 39762-6186, USA.
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MeSH Terms
Amino Acids / administration & dosage*
Human Growth Hormone / blood,  secretion*
Muscle, Skeletal / anatomy & histology,  drug effects,  physiology
Reg. No./Substance:
0/Amino Acids; 12629-01-5/Human Growth Hormone
Comment In:
Nutrition. 2002 Jul-Aug;18(7-8):683-4   [PMID:  12093457 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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