Document Detail

Use of ameroid constrictors in the development of renin-dependent hypertension in dogs.
MedLine Citation:
PMID:  1316513     Owner:  NLM     Status:  MEDLINE    
We describe methods for using ameroid constrictors to develop renin-dependent hypertension in dogs. A vascular-access-port was implanted in each dog and mean arterial blood pressure was monitored. Via a small flank incision, an ameroid constrictor was placed on the left renal artery and mean arterial blood pressure, plasma renin activity, and the response to angiotensin-converting enzyme inhibition measured during the subsequent 4 weeks. Placement of the constrictor on the left renal artery resulted in a significant increase in plasma renin activity which was accompanied by a significant hypertension (blood pressure greater than 140 mmHg). The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.). The results of this study indicate that ameroid constrictors provide a reliable method for establishing renin-dependent hypertension in dogs.
D P Brooks; T A Fredrickson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  42     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-06-15     Completed Date:  1992-06-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
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MeSH Terms
Biocompatible Materials* / adverse effects
Blood Pressure / drug effects
Disease Models, Animal
Heart Rate / drug effects
Hypertension, Renal / blood,  etiology*
Renal Artery / surgery
Renin / blood,  drug effects,  physiology*
Reg. No./Substance:
0/Biocompatible Materials; 0/Caseins; 0/Hydrogels; 9005-93-0/ameroid; EC

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