Document Detail


Use of alpha 2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system.
MedLine Citation:
PMID:  3734105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of clonidine, an alpha 2-adrenoreceptor agonist, and yohimbine, an alpha 2-adrenoreceptor antagonist, on blood pressure, heart rate, and plasma catecholamines in 12 patients with autonomic dysfunction. Clonidine (0.1 mg, orally) lowered blood pressure 18 +/- 3 torr in six subjects and raised it 5 +/- 1 torr in six. The change in blood pressure in response to this dose of clonidine was inversely proportional to the supine level of norepinephrine (P less than 0.05). Yohimbine (4-64 micrograms/kg) raised plasma norepinephrine and blood pressure in six patients with degenerative autonomic dysfunction. Yohimbine also attenuated by 50% (P less than 0.05) the hypotensive response to head-up tilt of patients with degenerative autonomic dysfunction. Clonidine depends upon postjunctional hypersensitivity and the degree of autonomic insufficiency to elicit its pressor response. In contrast, the pressor response to yohimbine is related to the capacity of the sympathetic nervous system to be activated and release norepinephrine. If plasma norepinephrine levels following yohimbine administration are monitored, the biochemical and hemodynamic response to the drug may provide a sensitive indication of the capacity of the sympathetic nervous system to be activated in patients with autonomic dysfunction.
Authors:
D Robertson; M R Goldberg; C S Tung; A S Hollister; R M Robertson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  78     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-81     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autonomic Nervous System Diseases / blood,  physiopathology*
Blood Pressure / drug effects
Clonidine / pharmacology*
Female
Humans
Hypotension, Orthostatic / physiopathology
Male
Middle Aged
Norepinephrine / blood
Shy-Drager Syndrome / blood,  physiopathology
Sympathetic Nervous System / physiopathology*
Yohimbine / pharmacology*
Grant Support
ID/Acronym/Agency:
GM15431/GM/NIGMS NIH HHS; HL14192/HL/NHLBI NIH HHS; RR00095/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
146-48-5/Yohimbine; 4205-90-7/Clonidine; 51-41-2/Norepinephrine
Comments/Corrections

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