Document Detail


Use of allopurinol and deferoxamine in cellular protection during ischemia.
MedLine Citation:
PMID:  1509342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During cellular ischemia and death, many changes occur in the cell. These include the build-up of purines and lipid peroxidation. In this study, we evaluated the effectiveness of allopurinol, which blocks purine breakdown, and deferoxamine, which inhibits lipid peroxidation, as cytoprotective agents. Rats were subjected to middle cerebral artery occlusion and were treated with high or low doses of allopurinol or high or low doses of deferoxamine, with normal saline used as a control. Treatments were given 1 hour before, 1 hour after, or 5 hours after occlusion. The outcome was based on neurological status and infarct size. Both infarct size and neurological status were found to be improved in all treatment groups when compared to controls. This study suggests that the use of these agents prevents cellular damage during ischemia.
Authors:
D S Soloniuk; E Perkins; J R Wilson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  38     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-23     Completed Date:  1992-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  110-3     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, State University of New York, Buffalo.
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / pharmacology*
Animals
Brain Ischemia / pathology*
Cell Death / drug effects*
Cerebral Infarction / pathology
Deferoxamine / pharmacology*
Rats
Chemical
Reg. No./Substance:
315-30-0/Allopurinol; 70-51-9/Deferoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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