| Use of allopurinol and deferoxamine in cellular protection during ischemia. | |
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MedLine Citation:
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PMID: 1509342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During cellular ischemia and death, many changes occur in the cell. These include the build-up of purines and lipid peroxidation. In this study, we evaluated the effectiveness of allopurinol, which blocks purine breakdown, and deferoxamine, which inhibits lipid peroxidation, as cytoprotective agents. Rats were subjected to middle cerebral artery occlusion and were treated with high or low doses of allopurinol or high or low doses of deferoxamine, with normal saline used as a control. Treatments were given 1 hour before, 1 hour after, or 5 hours after occlusion. The outcome was based on neurological status and infarct size. Both infarct size and neurological status were found to be improved in all treatment groups when compared to controls. This study suggests that the use of these agents prevents cellular damage during ischemia. |
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Authors:
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D S Soloniuk; E Perkins; J R Wilson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgical neurology Volume: 38 ISSN: 0090-3019 ISO Abbreviation: Surg Neurol Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-09-23 Completed Date: 1992-09-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367070 Medline TA: Surg Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 110-3 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, State University of New York, Buffalo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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pharmacology* Animals Brain Ischemia / pathology* Cell Death / drug effects* Cerebral Infarction / pathology Deferoxamine / pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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315-30-0/Allopurinol; 70-51-9/Deferoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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