Document Detail


Use of allometry in predicting anatomical and physiological parameters of mammals.
MedLine Citation:
PMID:  11833526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One challenge for veterinarians, animal facilities and research scientists is the making of physiological estimates appropriate to a variety of species for which data are often either completely lacking or are incomplete. Our intent in compiling the data in this paper is to provide the best possible database of normal physiological and anatomical values primarily (though not exclusively) for four common mammalian model species: mouse, rat, dog and man. In order to make those data as accessible and applicable as possible, we have presented the results of this study in the form of body-size dependent allometric equations in which some variable (Y) is expressed as a dependent function of body mass (M) in the power-law equation, Y = aM(b). By compiling these data, it is apparent that the resultant equations are quantitatively grouped (with similar slope or 'b' values). These emergent patterns provide insights into body-size dependent 'principles of design' that seem to dictate several aspects of design and function across species among all mammals. In general, the weights of most individual organs scale as a constant fraction of body mass (i.e. the body mass exponent, b approximately equal to 1.0). Biological rates (e.g. heart rate, respiratory rate) scale as b approximately equal to -1/4. Finally, volume-rates (the product of volume and rate) such as cardiac output, ventilation and oxygen uptake vary as b approximately equal to 3/4.
Authors:
S L Lindstedt; P J Schaeffer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory animals     Volume:  36     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-07     Completed Date:  2002-07-09     Revised Date:  2011-02-15    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-19     Citation Subset:  IM    
Affiliation:
Physiology and Functional Morphology Group, Department of Biological Sciences, Northern Arizona University, Flagstaff 86011-5640, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Laboratory / anatomy & histology*,  physiology*
Basal Metabolism
Biometry / methods*
Body Constitution / physiology*
Body Weight / physiology
Dogs
Humans
Mice
Organ Size / physiology
Rats
Species Specificity
Grant Support
ID/Acronym/Agency:
R01 HL41986-01/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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