Document Detail

Use of adenosine echocardiography for diagnosis of coronary artery disease.
MedLine Citation:
PMID:  2063759     Owner:  NLM     Status:  MEDLINE    
Two-dimensional echocardiography combined with exercise is sensitive and specific in the detection of coronary artery disease (CAD) by demonstrating transient abnormalities in wall motion. Frequently, however, patients cannot achieve maximal exercise because of various factors. Pharmacologic stress testing with intravenous adenosine was evaluated as a means of detecting CAD in a noninvasive manner. Patients with suspected CAD underwent echocardiographic imaging and simultaneous thallium 201 single-photon emission computed tomography during the intravenous administration of 140 micrograms/kg/min of adenosine. An increase in heart rate, decrease in blood pressure, and increase in double product were observed during adenosine administration. Initial observations revealed that wall motion abnormalities were induced by adenosine in areas of perfusion defects. The adenosine infusion was well tolerated, and symptoms disappeared within 1 to 2 minutes after termination of the infusion. Therefore preliminary observations suggest that adenosine echocardiography appears to be useful in the assessment of CAD.
W A Zoghbi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  122     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-07     Completed Date:  1991-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-92; discussion 302-6     Citation Subset:  AIM; IM    
Section of Cardiology Baylor College of Medicine, Methodist Hospital, Houston, TX 77030.
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MeSH Terms
Adenosine / adverse effects,  diagnostic use*,  pharmacology
Coronary Disease / radionuclide imaging*,  ultrasonography*
Echocardiography / methods*
Exercise Test
Hemodynamics / drug effects
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon / methods
Reg. No./Substance:
0/Thallium Radioisotopes; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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