| Use of additional oxytocin to reduce blood loss at elective caesarean section: A randomised control trial. | |
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MedLine Citation:
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PMID: 20218995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this prospective, randomised, double-blind, placebo-controlled study was to assess the effects of a 5-IU oxytocin bolus and placebo infusion versus a 5-IU oxytocin bolus and 30 IU infusion on the control of blood loss at elective lower segment caesarean section (C/S). METHODS: Participants with indication for elective C/S were randomly allocated to two groups. Group A, 360 women, received oxytocin 5 IU bolus and placebo; group B, 360 women received oxytocin 5 IU bolus and 30 IU infusion. Blood loss was estimated based on the haematocrit values before and 48 h after delivery. The primary outcome was the incidence of excessive bleeding (estimated blood loss of >1000 mL), while secondary outcomes included use of additional uterotonics, estimated blood loss, need for blood transfusion, duration of hospital stay and the incidence of adverse effects. RESULTS: No demographic difference was observed between groups. Mean estimated blood loss (P < 0.001) and the proportion of women with blood loss estimated to be greater than 1000 mL were significantly less for group B than for group A (relative risk (RR) 0.35, 95% confidence interval (CI) 0.20-0.63). In addition, more women in the group A required additional uterotonic agents (RR 0.35, 95% CI 0.22-0.56) and blood transfusion (RR 0.12, 95% CI 0.01-0.98). CONCLUSION: An additional oxytocin infusion after 5 IU oxytocin bolus infusion at elective C/S may reduce blood loss and required blood transfusion. |
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Authors:
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Kemal Güngördük; Osman Asicioglu; Ozgu Celikkol; Yusuf Olgac; Cemal Ark |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Australian & New Zealand journal of obstetrics & gynaecology Volume: 50 ISSN: 1479-828X ISO Abbreviation: Aust N Z J Obstet Gynaecol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-07-13 Revised Date: 2010-08-02 |
Medline Journal Info:
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Nlm Unique ID: 0001027 Medline TA: Aust N Z J Obstet Gynaecol Country: Australia |
Other Details:
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Languages: eng Pagination: 36-9 Citation Subset: IM |
Affiliation:
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Erzincan Military Hospital, Turkey. maidenkemal@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cesarean Section* Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Length of Stay Oxytocics / administration & dosage* Oxytocin / administration & dosage* Placebos Postpartum Hemorrhage / prevention & control* Pregnancy Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 0/Placebos; 50-56-6/Oxytocin |
| Comments/Corrections | |
Erratum In:
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Aust N Z J Obstet Gynaecol. 2010 Apr;50(2):206 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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