| Use of abciximab during infrainguinal peripheral vascular interventions: initial experience. | |
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MedLine Citation:
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PMID: 12773673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the use of abciximab as an adjunct during infrainguinal angioplasty. MATERIALS AND METHODS: Abciximab was used in conjunction with recanalization techniques and angioplasty to treat stenoses or occlusions in 16 patients: 10 patients had high-grade stenoses or occlusions longer than 5 cm in the superficial femoral artery and popliteal artery, and six patients had stenoses or occlusions below the popliteal artery. All patients received a bolus of heparin after arterial access was achieved. Abciximab was administered by means of a weight-base nomogram that consisted of an initial bolus followed by an overnight infusion. Technical success was defined as a less than 30% residual stenosis after angioplasty. Patients were carefully followed up for possible postprocedural complications. Platelet counts were monitored for 24 hours. RESULTS: Technical success was achieved in 15 (94%) of 16 patients. One occlusion of the superficial femoral artery could not be crossed. There was a mean postprocedural increase of 0.23 in the ankle-brachial index. There was no significant effect on platelet count. Two minor complications occurred. One major complication occurred; this was a groin hematoma, which required a blood transfusion. CONCLUSION: The use of abciximab as an adjunct during complex infrainguinal arterial interventions appears promising, on the basis of initial experience. |
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Authors:
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S William Stavropoulos; Jeffrey A Solomon; Michael C Soulen; Timothy W I Clark; Richard D Shlansky-Goldberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 227 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-29 Completed Date: 2003-06-20 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19010, USA. stav@rad.upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon* Antibodies, Monoclonal / therapeutic use* Arterial Occlusive Diseases / therapy* Constriction, Pathologic / therapy Female Femoral Artery Heparin / therapeutic use Humans Immunoglobulin Fab Fragments / therapeutic use* Male Middle Aged Peripheral Vascular Diseases / therapy* Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors Popliteal Artery |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 143653-53-6/abciximab; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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