Document Detail


Use of abciximab during infrainguinal peripheral vascular interventions: initial experience.
MedLine Citation:
PMID:  12773673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the use of abciximab as an adjunct during infrainguinal angioplasty.
MATERIALS AND METHODS: Abciximab was used in conjunction with recanalization techniques and angioplasty to treat stenoses or occlusions in 16 patients: 10 patients had high-grade stenoses or occlusions longer than 5 cm in the superficial femoral artery and popliteal artery, and six patients had stenoses or occlusions below the popliteal artery. All patients received a bolus of heparin after arterial access was achieved. Abciximab was administered by means of a weight-base nomogram that consisted of an initial bolus followed by an overnight infusion. Technical success was defined as a less than 30% residual stenosis after angioplasty. Patients were carefully followed up for possible postprocedural complications. Platelet counts were monitored for 24 hours.
RESULTS: Technical success was achieved in 15 (94%) of 16 patients. One occlusion of the superficial femoral artery could not be crossed. There was a mean postprocedural increase of 0.23 in the ankle-brachial index. There was no significant effect on platelet count. Two minor complications occurred. One major complication occurred; this was a groin hematoma, which required a blood transfusion.
CONCLUSION: The use of abciximab as an adjunct during complex infrainguinal arterial interventions appears promising, on the basis of initial experience.
Authors:
S William Stavropoulos; Jeffrey A Solomon; Michael C Soulen; Timothy W I Clark; Richard D Shlansky-Goldberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  227     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-29     Completed Date:  2003-06-20     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-61     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19010, USA. stav@rad.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon*
Antibodies, Monoclonal / therapeutic use*
Arterial Occlusive Diseases / therapy*
Constriction, Pathologic / therapy
Female
Femoral Artery
Heparin / therapeutic use
Humans
Immunoglobulin Fab Fragments / therapeutic use*
Male
Middle Aged
Peripheral Vascular Diseases / therapy*
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
Popliteal Artery
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 9005-49-6/Heparin; X85G7936GV/abciximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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