| Use of zidovudine-sparing HAART in pregnant HIV-infected women in Europe: 2000-2009. | |
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MedLine Citation:
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PMID: 21499113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increasing numbers of women in resource-rich settings are prescribed zidovudine (ZDV)-sparing highly active antiretroviral therapy (HAART) in pregnancy. We compare ZDV-sparing with ZDV-containing HAART in relation to maternal viral load at delivery, mother-to-child transmission (MTCT) of HIV, and congenital abnormality. METHODS: This is an analysis of data from the National Study of HIV in Pregnancy and Childhood and the European Collaborative Study. Data on 7573 singleton births to diagnosed HIV-infected women between January 2000 and June 2009 were analyzed. Logistic regression models were fitted to estimate adjusted odds ratios (AORs). RESULTS: Overall, 15.8% (1199 of 7573) of women received ZDV-sparing HAART, with increasing use between 2000 and 2009 (P < 0.001). Nearly a fifth (18.4%) of women receiving ZDV-sparing HAART in pregnancy had a detectable viral load at delivery compared with 28.6% of women on ZDV-containing HAART [AOR 0.90; 95% confidence interval (CI): 0.72 to 1.14, P = 0.4]. MTCT rates were 0.8% and 0.9% in the ZDV-sparing and ZDV-containing groups, respectively (AOR 1.81; 95% CI: 0.77 to 4.26, P = 0.2). The congenital abnormality rate was the same in both groups (2.7%, AOR 0.98; 95% CI: 0.66 to 1.45, P = 0.9), with no significant difference between the groups in a subanalysis of pregnancies with first trimester HAART exposure (AOR 0.79; 95% CI: 0.48 to 1.30, P = 0.4). CONCLUSIONS: We found no difference in risk of detectable viral load at delivery, MTCT, or congenital abnormality when comparing ZDV-sparing with ZDV-containing HAART. With increasing use of ZDV-sparing HAART, continued monitoring of pregnancy outcomes and long-term consequences of in utero exposure to these drugs is required. |
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Authors:
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Shema Tariq; Claire L Townsend; Mario Cortina-Borja; Trinh Duong; Jonathan Elford; Claire Thorne; Pat A Tookey; ; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 57 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-22 Completed Date: 2011-10-24 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 326-33 Citation Subset: IM; X |
Affiliation:
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Department of Public Health, City University London, London, United Kingdom. shema.tariq.2@city.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / therapeutic use* Antiretroviral Therapy, Highly Active* CD4 Lymphocyte Count Europe / epidemiology Female HIV Infections / drug therapy*, epidemiology* Humans Infant Infectious Disease Transmission, Vertical / prevention & control Pregnancy Pregnancy Complications, Infectious / drug therapy*, epidemiology Retrospective Studies Time Factors Viral Load Zidovudine / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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081082//Wellcome Trust; G0501895//Medical Research Council; G0701648//Medical Research Council; G0701648//Medical Research Council; G0701648(85538)//Medical Research Council; //Department of Health; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 30516-87-1/Zidovudine |
| Investigator | |
Investigator/Affiliation:
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C Giaquinto / ; O Rampon / ; A Mazza / ; A De Rossi / ; I Grosch Wörner / ; J Mok / ; Ma I de José / ; B Larrú Martínez / ; H J Scherpbier / ; M Kreyenbroek / ; M H Godfried / ; F J B Nellen / ; K Boer / ; L Navér / ; B Anzén / ; K Lidman / ; J Levy / ; P Barlow / ; Y Manigart / ; M Hainaut / ; T Goetghebuer / ; B Brichard / ; J De Camps / ; N Thiry / ; G Deboone / ; H Waterloos / ; A De Maria / ; A Mûr / ; A Payà / ; M A López-Vilchez / ; R Carreras / ; N H Valerius / ; V Rosenfeldt / ; O Coll / ; A Suy / ; J M Perez / ; C Fortuny / ; J Boguña / ; V Savasi / ; A Viganò / ; V Giacomet / ; C Cerini / ; C Raimondi / ; G Zuccotti / ; S Alberico / ; M Rabusin / ; M Bernardon / ; W Buffolano / ; R Tiseo / ; P Martinelli / ; M Sansone / ; G Maruotti / ; A Agangi / ; C Tibaldi / ; S Marini / ; G Masuelli / ; C Benedetto / ; T Niemieç / ; M Marczynska / ; S Dobosz / ; J Popielska / ; A Oldakowska / ; Janet Masters / ; Hiwot Haile-Selassie / ; Clare French / ; Icina Shakes / |
| Comments/Corrections | |
Erratum In:
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J Acquir Immune Defic Syndr. 2011 Aug 15;57(5):e117 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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