| The Use of a Single Von Willebrand Factor-Containing, Plasma-Derived FVIII Product in Hemophilia a Immune Tolerance Induction - U.S. Experience. | |
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MedLine Citation:
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PMID: 21883884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Inhibitors are a serious complication for patients with severe hemophilia A. Immune tolerance induction (ITI) is the primary method for eradicating these inhibitors. The role of type of concentrate and in particular the use of von Willebrand factor-containing, plasma-derived factor VIII (VWF/pd-FVIII) concentrate in primary or rescue ITI remains unclear. Objectives: To report retrospective data collection on the use of a single VWF/pd-FVIII concentrate in primary and rescue ITI. Methods: Retrospective chart review of hemophilia A inhibitor patients at 11 US institutions who received VWF/pd-FVIII concentrate in primary or rescue ITI. Results: Primary ITI was carried out in 8 inhibitor patients with a 75% complete and partial success. Secondary ITI was carried out in 25 inhibitor patients with 52% attaining complete or partial success. Conclusions: This report represents the largest group of primarily pediatric, high-titer inhibitor patients treated with a single VWF/pd-FVIII concentrate. It adds retrospective data to the use of VWF-containing plasma-derived factor VIII concentrate in primary and rescue ITI particularly in those patients with characteristics for poor response to ITI. |
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Authors:
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M Kurth; J Puetz; P Kouides; J Sanders; C Sexauer; J Bernstein; R Gruppo; M Manco-Johnson; E J Neufeld; N Rodriguez; B Wicklund; D Quon; L Aledort |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-28 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: - ISSN: 1538-7836 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 International Society on Thrombosis and Haemostasis. |
Affiliation:
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Department of Pediatrics, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN Department of Pediatrics, Cardinal Glennon Children's Medical Center, St. Louis MO Department of Medicine, University of Rochester Medical Center, Rochester, NY Department of Pediatrics, Cook Children's Hospital, Fort Worth, TX Department of Pediatrics, Oklahoma University Health Science Center, Oklahoma City, OK Children's Center for Cancer and Blood Diseases, Las Vegas, NV Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH Department of Pediatrics, University of Colorado and Health Sciences Center, Children's Hospital Colorado, Aurora, CO Department of Pediatrics, Children's Hospital of Boston, Boston, MA Department of Pediatrics, University of Texas-Texas Medical Center, Houston, TX Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO Department of Medicine, Orthapedic Hospital, Los Angeles, CA Department of Medicine, Mount Sinai Medical Center, New York City, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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