Document Detail

Use of serum homocysteine to predict cardiovascular disease in Korean men with or without metabolic syndrome.
MedLine Citation:
PMID:  22563214     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects. The subjects were divided into four subgroups: 34 CVD/MetS, 104 CVD, 77 MetS, and 213 normal subgroups. The mean Hcy was significantly higher, whereas HDL and intake of vitamin B(1) and B(2) were lower in the CVD group (P < 0.05) than non-CVD group. When compared to the control group, subjects with CVD/MetS, CVD and MetS exhibited high Hcy levels, with the highest observed in the CVD/MetS subgroup (P < 0.001). Multivariate stepwise linear regression between CVD and markers of CVD showed Hcy significantly correlated with CVD (P < 0.05). To predict CVD based on Hcy, Hcy threshold of 11.72 µM in non-MetS subjects had an area under the curve (AUC) of 0.664 (95% CI 0.598-0.731). In MetS subjects, the AUC was 0.618 and Hcy threshold was 13.32 µM (95% CI 0.509-0.726). The results of our study show that the presence of MetS needs to be considered when using Hcy levels for predicting CVD.
Ji Yeon Kang; Ill Keun Park; Ji Young Lee; Sook Hee Sung; Youn Koun Chang; Yoo Kyoung Park; Tae In Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-25
Journal Detail:
Title:  Journal of Korean medical science     Volume:  27     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-08-31     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  500-5     Citation Subset:  IM    
Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea.
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MeSH Terms
Area Under Curve
Cardiovascular Diseases / blood*,  complications,  epidemiology
Case-Control Studies
Cholesterol, HDL / blood
Dietary Supplements
Homocysteine / blood
Linear Models
Metabolic Syndrome X / complications*
Middle Aged
Predictive Value of Tests
Republic of Korea / epidemiology
Reg. No./Substance:
0/Cholesterol, HDL; 454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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