| Use of serotonergic antidepressants and bleeding risk in orthopedic patients. | |
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MedLine Citation:
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PMID: 20179499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Selective serotonin reuptake inhibitors have been associated with an increased bleeding tendency. Information on the impact of a possible impaired hemostasis associated with the perioperative use of selective serotonin reuptake inhibitors is limited. This study aimed to determine the association between the perioperative use of selective serotonin reuptake inhibitors and the amount of blood loss during surgery and perioperative transfusion requirements. METHODS: The authors conducted a retrospective cohort study among patients who underwent elective primary total hip arthroplasty in two hospitals from the period of July 1, 2004 until July 1, 2008. The index group included all users of both serotonergic and nonserotonergic antidepressants. The reference group included a random sample (ratio 1:3) of nonusers. The primary outcome was the amount of intraoperative blood loss. The requirement for blood transfusion was a secondary outcome. The outcomes were adjusted for confounding factors (comorbidity and comedication) using regression techniques. RESULTS: The index group included 66 users of serotonergic and 29 users of nonserotonergic antidepressants, and the reference group included 285 patients. After adjustment for confounding factors, mean blood loss during surgery was significantly higher in the users of selective serotonin reuptake inhibitors when compared with the reference group: 95 ml (95% CI 9-181). Mean blood loss in the users of nonserotonergic antidepressants did not differ from the reference group. Users of antidepressants did not have a higher risk for transfusion. CONCLUSIONS: Patients undergoing total hip arthroplasty who continue the use of serotonergic antidepressants show a significantly higher, but clinically unimportant, intraoperative blood loss, without an increase in perioperative transfusion requirements. |
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Authors:
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Ingrid M M van Haelst; Toine C G Egberts; Hieronymus J Doodeman; Han S Traast; Bart J Burger; Cor J Kalkman; Wilton A van Klei |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Anesthesiology Volume: 112 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-24 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 631-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Pharmacy, Medical Center Alkmaar, Alkmaar, The Netherlands. i.van.haelst@mca.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthesia Antidepressive Agents / adverse effects* Arthroplasty, Replacement, Hip Blood Loss, Surgical / physiopathology* Blood Transfusion Cohort Studies Comorbidity Female Humans Logistic Models Male Middle Aged Orthopedic Procedures* Retrospective Studies Risk Serotonin Uptake Inhibitors / adverse effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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