Document Detail


Use of Palivizumab in Germany: Data from 2002-2007.
MedLine Citation:
PMID:  21509705     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The German Palivizumab Registry refers to a post-marketing observational study of palivizumab administration during 5 consecutive respiratory syncytial virus (RSV) seasons (2002/2003 -2006/2007). PATIENTS AND METHODS: The registry provided data on drug administration, risk factors for complicated RSV disease, rehospitalisation rates for infants receiving RSV prophylaxis, and parental adherence. 49 608 administrations were documented in 10 686 patients (average of 4.6 per patient). RESULTS: 35% of infants received >5 monthly injections. Median gestational age at birth was 29 weeks (range 23-41 weeks), median birth weight was 1 350 g (range 320-6 620 g), 3% were attending day care, 46% lived in a household with children <12 years, 18% were exposed to tobacco smoke at home, 10% had a family history of asthma, and 31% had congenital heart disease. The risk of serious adverse events possibly or probably related to palivizumab administration was 0.2 per 1 000 administrations. According to a worst-case calculation, the rehospitalisation rate related to RSV infection was 2.5% in children who received prophylaxis. CONCLUSION: The German Palivizumab Registry provides a comprehensive dataset describing the use of palivizumab in Germany from 2002 to 2007, and areas for improvement identified in this registry can be applied to enhance the use of palivizumab in the future.
Authors:
A Simon; H Nowak; R Sterz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  Klinische Padiatrie     Volume:  -     ISSN:  1439-3824     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Children's Hospital Medical Center, Pediatric Hematology and Oncology, Homburg, Germany.
Vernacular Title:
Anwendung von Palivizumab in Deutschland - Daten von 2002-2007.
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