| Use of oral contraceptives in pregnancy and major structural birth defects in offspring. | |
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MedLine Citation:
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PMID: 20087193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Oral contraceptives (OCs) are the most commonly used reversible contraceptive method among US women. Although the majority of previous studies have reported no association between OC use during pregnancy and birth defects, some studies have reported increased occurrence of neural tube defects, limb reduction defects, and urinary tract anomalies. METHODS: We assessed OC use among mothers who participated in the multisite, case-control, National Birth Defects Prevention Study. Mothers of 9986 infants with 32 types of birth defects and 4000 infants without birth defects were included. RESULTS: Maternal OC use during the first 3 months of pregnancy was associated with an increased odds ratio for 2 of 32 birth defects: hypoplastic left heart syndrome (adjusted odds ratio = 2.3 [95% confidence interval = 1.3-4.3) and gastroschisis (1.8 [1.3-2.7]). CONCLUSION: Previous reports of associations between OC use and specific types of anomalies were not corroborated. Given that associations were assessed for 32 types of birth defects, our findings of 2 increased associations between OC use and gastroschisis and hypoplastic left heart syndrome should be interpreted as hypotheses until they can be evaluated further. Overall, our findings are consistent with the majority of previous studies that found women who use OCs during early pregnancy have no increased risk for most types of major congenital malformations. |
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Authors:
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Dorothy Kim Waller; Michael Shayne Gallaway; Lockwood G Taylor; Tunu A Ramadhani; Mark A Canfield; Angela Scheuerle; Sonia Hern?ndez-Diaz; Carol Louik; Adolfo Correa; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 21 ISSN: 1531-5487 ISO Abbreviation: Epidemiology Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-18 Completed Date: 2010-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 232-9 Citation Subset: IM |
Affiliation:
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The University of Texas, Houston Health Science Center, School of Public Health, Houston, TX 77030, USA. Kim.Waller@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology* Abnormalities, Multiple / chemically induced, epidemiology Adolescent Adult Case-Control Studies Confidence Intervals Congenital Abnormalities / epidemiology, etiology Contraceptives, Oral / adverse effects* Female Gastroschisis / chemically induced, epidemiology Humans Hypoplastic Left Heart Syndrome / chemically induced, epidemiology Odds Ratio Pregnancy Pregnancy Trimester, First / drug effects Risk Factors United States / epidemiology Urinary Tract / abnormalities Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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PA 02081//PHS HHS; U50/CCU613232//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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