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Use of Oral Antidiabetic Drugs (Metformin and Pioglitazone) in Diabetic Patients with Breast Cancer: How Does It Effect Serum Hif-1 Alpha and 8Ohdg Levels?
MedLine Citation:
PMID:  23244125     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: The aim was to investigate indicators related to DNA damage and cancer pathogenesis in Type II diabetes cases with breast cancer. It was planned to evaluate the relationship between these markers with oral antidiabetic drugs. Research Design and Methods: Fourty patients and 10 healthy individuals were included in the study. HIF-1αand 8-OHdG are examined in blood samples taken from these individuals with an ELISA Kit. Statistical analysis of data was performed with 95% confidence using Windows package program SPSS 15.0. Results: HIF-1αparameters were found to be meaningfully higher in the patient group than the controls in both pretreatment and posttreatment periods (p<0.05). No significant differences in terms of 8-OHdG between patients and controls. However, posttreatment serum HIF-1αve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone. Conversely, serum 8-OHdG levels decreased significantly in these patients. When patients were evaluated according to the treatment groups (pioglitazone vs. metfformin) no significant differences in terms of serum HIF-1? and 8-OHdG levels between treatment groups. Conclusions: HIF-1αlevels decreased significantly in the patient group receiving metformin. However, there was no significant difference in terms of HIF-1αlevels in the patients receiving pioglitazone.
Authors:
Harman Ece; Erten Cigdem; Kucukzeybek Yuksel; Dirican Ahmet; Er Hakan; Tarhan Mustafa Oktay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  13     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  5143-8     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism Disease, Katip Celebi University, Izmir Ataturk Training and Research Hospital, Izmir, Turkey E-mail : ecarmu@gmail.com.
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