Document Detail

Use of Myocardial Strain Imaging by Echocardiography for the Early Detection of Cardiotoxicity in Patients During and After Cancer Chemotherapy - A Systematic Review.
MedLine Citation:
PMID:  24703918     Owner:  NLM     Status:  Publisher    
The literature exploring the utility of advanced echocardiographic techniques (such as deformation imaging) in the diagnosis and prognostication of patients receiving potentially cardiotoxic cancer therapy has involved relatively small trials in the research setting. In this systematic review of the current literature, we describe echocardiographic myocardial deformation parameters in 1504 patients during or after cancer chemotherapy for three clinically relevant scenarios. The systematic review was performed following the PRISMA guidelines using EMBASE (1974 to November 2013) and MEDLINE (1946 to November 2013) databases. All studies of early myocardial changes with chemotherapy demonstrate that alterations of myocardial deformation precede significant change in LVEF. Using tissue Doppler-based strain imaging, peak systolic longitudinal strain rate has most consistently detected early myocardial changes during therapy, while with speckle tracking echocardiography (STE), peak systolic global longitudinal strain (GLS) appears to be the best measure. A 10-15% early reduction in GLS by STE during therapy appears to be the most useful parameter for the prediction of cardiotoxicity defined as a drop in left ventricular ejection fraction (LVEF) or heart failure. In late survivors of cancer, measures of global radial and circumferential strain are consistently abnormal, even in the context of normal LVEF, but their clinical value in predicting subsequent ventricular dysfunction or heart failure has not been explored. Thus, this systematic review confirms the value of echocardiographic myocardial deformation parameters for the early detection of myocardial changes and prediction of cardiotoxicity in patients receiving cancer therapy.
Paaladinesh Thavendiranathan; Frédéric Poulin; Ki-Dong Lim; Juan Carlos Plana; Anna Woo; Thomas H Marwick
Related Documents :
14077808 - Effect of an aldosterone antagonist (spironolactone) on patients with severe congestive...
2935328 - Positive inotropic therapy for short-term support and long-term management of patients ...
1894718 - Peripheral circulatory response in cardiac failure.
6816788 - Cardiovascular effects of antidepressants.
8665978 - Microvascular incompetence and the failure of hearts to recover contractile function af...
23029728 - Isolated non-compacted right ventricular myocardium.
Publication Detail:
Type:  REVIEW     Date:  2014-3-21
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  -     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrocardiographic Parameters and Fatal Arrhythmic Events in Patients with Brugada Syndrome: Combi...
Next Document:  Challenges facing early career academic cardiologists.