Document Detail


Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals.
MedLine Citation:
PMID:  12802416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.
Authors:
S V Litvinova; I A Kostanyan; V V Aristova; A L Kalyuzhnyi; V V Shul'govskii; N N Terebilina; L F Panchenko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2004-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
Affiliation:
Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / metabolism
Drug Tolerance / physiology*
Female
Homeostasis
Male
Morphine / pharmacology*
Narcotics / metabolism*
Neoplasm Proteins / metabolism*
Neprilysin / antagonists & inhibitors,  metabolism
Pain / metabolism*
Pain Measurement
Peptide Fragments / metabolism*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Narcotics; 0/Neoplasm Proteins; 0/Peptide Fragments; 0/cell differentiation factor 8.2-kDa; 57-27-2/Morphine; EC 3.4.24.11/Neprilysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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