| Use of GnRH depot analogue in the treatment of uterine fibroids. | |
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MedLine Citation:
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PMID: 2150737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twelve patients with symptomatic uterine fibroid were treated with Goserelin acetate, a depot Gn-RH analogue administered s.c. in a dosage of 3.6 mg every 28 days for a 6 month period. Mean age of the patients was 39 (26-47). A menopausal-like state, evidenced by hot flushes, depression, vaginal dryness, hysteroscopic endometrial atrophy, and hormonal values (FSH, LH, E2), was seen in all patients. After only two months of treatment, a significant reduction was noted in the size of the fibroid, being even greater than that in the following four months. Only one patient in the series underwent surgery. General tolerability of the drug was optimal. These data suggest the efficiency of this type of treatment in obtaining a significant reduction of fibroid volume as well as subjective symptomatology. The cost-benefit ratio is optimal, allowing postponement of surgery and the possibility of vaginal, as opposed to abdominal, hysterectomy and affronting problems of anaesthesiology and post-operative recovery for patients "at risk". |
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Authors:
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G Auber; G Ricci; F Barciulli; R Pregazzi; R L D'Ancona; F G Toffoletti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta Europaea fertilitatis Volume: 21 ISSN: 0587-2421 ISO Abbreviation: Acta Eur. Fertil. Publication Date: 1990 Jul-Aug |
Date Detail:
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Created Date: 1991-05-16 Completed Date: 1991-05-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300660 Medline TA: Acta Eur Fertil Country: ITALY |
Other Details:
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Languages: eng Pagination: 185-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Trieste, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence Buserelin / adverse effects, analogs & derivatives*, pharmacokinetics, therapeutic use Estradiol / blood Female Follicle Stimulating Hormone / blood Gonadotropin-Releasing Hormone / analogs & derivatives Goserelin Humans Injections, Subcutaneous Luteinizing Hormone / blood Middle Aged Molecular Sequence Data Ovary / drug effects Pituitary Gland / drug effects Progesterone / blood Prolactin / blood Thyroxine / blood Triiodothyronine / blood Uterine Neoplasms / drug therapy*, metabolism, pathology Uterus / pathology |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone; 57982-77-1/Buserelin; 65807-02-5/Goserelin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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