| Use of the GlucoWatch biographer in children with type 1 diabetes. | |
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MedLine Citation:
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PMID: 12671113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether use of the GlucoWatch biographer improves glucose control in children and adolescents with type 1 diabetes. METHODS: Forty children in poor glucose control (glycohemoglobin [HbA1c] >8%) were randomized to diabetes management with or without glucose monitoring using the biographer. Conventional glucose monitoring was performed 4 times daily in both groups. Those randomized to the biographer group were asked to wear the device 4 times per week for 3 months (intervention phase) and to perform blood glucose monitoring if the biographer alerted them that glucose was < or =70 mg/dL (3.9 mmol/L) or > or =300 mg/dL (16.7 mmol/L). After 3 months, all patients received biographers and were followed for 6 months (observation phase). HbA1c values were determined at baseline and after 1, 3, 6, and 9 months. RESULTS: The median HbA1c was 8.6% and 8.9% (control versus biographer) at baseline and was significantly lower in the biographer group after 3 months (8.4% vs 9%). More hypoglycemia was detected when subjects were wearing the biographer, especially at night. No severe hypoglycemia occurred. During the observation phase, HbA1c values at 6 months were 8.5% and 8.3% and at 9 months were 8.6% and 8.4% in the control and biographer groups, respectively. Two children dropped out of the study, 1 because of skin irritation from using the device. CONCLUSIONS: The GlucoWatch biographer was well tolerated by children and adolescents and significantly improved glucose control compared with standard therapy. The use of the biographer with an alarm to detect nocturnal hypoglycemia has the potential to increase the safety of diabetes management in children. |
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Authors:
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H Peter Chase; Mary D Roberts; Clare Wightman; Georgeanna Klingensmith; Satish K Garg; Michelle Van Wyhe; Shashi Desai; Wesley Harper; Margarita Lopatin; Miroslaw Bartkowiak; Janet Tamada; Richard C Eastman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatrics Volume: 111 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-02 Completed Date: 2003-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 790-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Glucose Self-Monitoring / instrumentation*, methods* Child Diabetes Mellitus, Type 1 / blood*, drug therapy, urine Female Glucose / metabolism Hemoglobin A, Glycosylated / metabolism Hemoglobinuria / metabolism Humans Hypoglycemia / chemically induced Infusion Pumps, Implantable Injections, Subcutaneous Insulin / administration & dosage, therapeutic use Insulin Infusion Systems Male Quality of Life |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 11061-68-0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
Comment In:
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Pediatrics. 2003 Apr;111(4 Pt 1):885
[PMID:
12671127
]
Pediatrics. 2004 Jan;113(1 Pt 1):175-6; author reply 175-6 [PMID: 14702477 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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