Document Detail


Use of gemcitabine with multi-stage surgical resection as successful second-line treatment of metastatic pancreatoblastoma.
MedLine Citation:
PMID:  23042010     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pancreatoblastoma is a rare pediatric pancreatic malignancy. It confers a worse prognosis if there is metastatic or unresectable disease. We report a case of a 12-year-old boy who presented with pancreatoblastoma of the head of the pancreas with multiple intrahepatic metastases. We successfully treated him using aggressive chemotherapy, multi-stage surgery, and gemcitabine chemotherapy, which has not been described as treatment for pancreatoblastoma. Rare childhood malignancies such as pancreatoblastoma require a coordinated, multidisciplinary approach and frequent reassessment of therapeutic interventions. Complete surgical resection is important for cure and may require complex, aggressive, multiple-stage surgical procedures with concurrent or novel chemotherapy.
Authors:
Mark J Belletrutti; David Bigam; Ravi Bhargava; Paul Grundy
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  35     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-21     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e7-10     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Pediatric Hematology, Oncology and Palliative Care, Stollery Children's Hospital, Edmonton, AB, Canada. mark.belletrutti@albertahealthservices.ca
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites, Antineoplastic / therapeutic use*
Child
Combined Modality Therapy
Deoxycytidine / analogs & derivatives*,  therapeutic use
Humans
Liver Neoplasms / pathology,  therapy*
Male
Pancreatectomy*
Pancreatic Neoplasms / secondary,  therapy*
Prognosis
Salvage Therapy*
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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