| The use of F-18 choline PET in the assessment of bone metastases in prostate cancer: correlation with morphological changes on CT. | |
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MedLine Citation:
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PMID: 19588206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: F-18 fluor choline-positron emission tomography/computed tomography (FCH-PET/CT) has emerged as a new diagnostic tool for the imaging of prostate cancer. In this study, we have evaluated the potential role of FCH-PET/CT for the assessment of bone metastases in patients with prostate cancer. Furthermore, we assessed the pattern of metabolic uptake by FCH in relation to morphologic changes on CT. METHODS: Seventy men with biopsy-proven prostate cancer underwent FCH-PET/CT for preoperative staging or follow-up evaluation. Thirty-two patients were evaluated preoperatively, and 38 patients were referred for postoperative evaluation of suspected recurrence or progression based on clinical algorithms. PET imaging consisted of a dynamic PET/CT acquisition of the pelvic region during 8 min (1 min frames) starting 1 min after i.v. injection of 4.07 MBq/kg/bw FCH, which was followed immediately by a semi-whole body acquisition. RESULTS: Overall, 262 lesions showed increased uptake on FCH-PET. Two hundred ten lesions (210 of 262) were interpreted as bone metastases. The mean of maximum standardized uptake value (SUV(max)) in all malignant lesions was 8.1 +/- 3.9. Forty-nine lesions (24%) had no detectable morphological changes on CT-probably due to bone marrow metastases. Fifty-six sclerotic lesions (having a Hounsfield unit (HU) level of more than 825) were interpreted as highly suspicious for metastatic bone disease on CT and/or other imaging modalities such as the bone scan, but showed no FCH uptake. There was a significant correlation between tracer uptake as assessed by SUV and the density of sclerotic lesions by HU (r = -0.52, p < 0.001). The sensitivity, specificity, and accuracy of FCH-PET/CT in detecting bone metastases from prostate cancer was 79%, 97%, and 84%, respectively. CONCLUSION: FCH-PET/CT showed promising results for the early detection of bone metastases in prostate cancer patients. We have found that a HU level of above 825 is associated with an absence of FCH uptake. Almost all of the FCH-negative sclerotic lesions were detected in patients who were under hormone therapy, which raises the possibility that these lesions might no longer be viable. However, clarification and the prognostic value of such lesions require further research. |
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Authors:
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Mohsen Beheshti; Reza Vali; Peter Waldenberger; Friedrich Fitz; Michael Nader; Josef Hammer; Wolfgang Loidl; Christian Pirich; Ignac Fogelman; Werner Langsteger |
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Publication Detail:
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Type: Duplicate Publication; Journal Article Date: 2009-07-09 |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 12 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-23 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 98-107 Citation Subset: IM |
Affiliation:
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PET/CT Center Linz, St. Vincent's Hospital-Nuclear Medicine & Endocrinology, Linz, Austria. mohsen.beheshti@bhs.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Neoplasms / radiography, radionuclide imaging*, secondary* Choline / diagnostic use* Disease Progression Fluorine Radioisotopes Hormones / therapeutic use Humans Male Positron-Emission Tomography* Prostatic Neoplasms / drug therapy, pathology, radiography, radionuclide imaging* Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Hormones; 62-49-7/Choline |
| Comments/Corrections | |
Erratum In:
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Mol Imaging Biol. 2010 Jun;12(3):360 |
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