Document Detail


Use of Emla prior to circumcision.
MedLine Citation:
PMID:  8913418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are insufficient data to support the use of Emla cream for circumcision in newborn infants at this time. There are no studies that adequately address safety or efficacy. Before efficacy studies can be evaluated, pharmacodynamic studies need to be completed. These studies are in progress and are closed (personal communication, Vivian Broach BSPharm, Astra Pharmaceutical Product Information Service, Astra Pharmaceutical, Westborough, MA, June 8, 1995). Subsequent studies should be performed within the first 72 hours of birth and assess the following parameters: (1) serum concentrations of metHb, lidocaine, and prilocaine and its metabolites from time zero to at least 24 hours after application of the cream; (2) application time and dose applied should be varied to assess differences in absorption, as well as onset and duration of analgesia; (3) application technique could be varied to assess the depth of analgesia, that is, application to the inner and outer surface of the prepuce versus the outer surface only. Until these studies are completed, routine use of Emla cream for local anesthesia during circumcision cannot be recommended.
Authors:
T D Puthoff; J A Visconti; M M Tschampel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  30     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1327-30     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Ohio State University, Columbus, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Local / adverse effects,  therapeutic use*
Circumcision, Male*
Drug Combinations
Humans
Infant, Newborn
Lidocaine / adverse effects,  therapeutic use*
Male
Methemoglobinemia / chemically induced
Prilocaine / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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