Document Detail

Use of dicarboxylic acids in type 2 diabetes.
MedLine Citation:
PMID:  22242741     Owner:  NLM     Status:  MEDLINE    
Even-number, medium-chain dicarboxylic acids (DAs), naturally occurring in higher plants, are a promising alternative energy substrate. Unlike the homologous fatty acids, DAs are soluble in water as salts. They are β-oxidized, providing acetyl-CoA and succinyl-CoA, the latter being an intermediate of the tricarboxylic acid cycle. Sebacic acid and dodecanedioic acid, DAs with 10 and 12 carbon atoms respectively, provide 6.6 and 7.2 kcal g⁻¹ each; therefore, their energy density is intermediate between glucose and fatty acids. Dicarboxylic acids have been proved to be safe in both experimental animals and humans, and their use has recently been proposed in diabetes. Studies in animals and humans with type 2 diabetes showed that oral administration of sebacic acid improved glycaemic control, probably by enhancing insulin sensitivity, and reduced hepatic gluconeogenesis and glucose output. Moreover, dodecanedioic acid intake reduced muscle fatigue during exercise in subjects with type 2 diabetes, suggesting an improvement of energy utilization and 'metabolic flexibility'. In this article, we review the natural sources of DAs, their fate in animals and humans and their effect in improving glucose metabolism in type 2 diabetes.
Geltrude Mingrone; Lidia Castagneto-Gissey; Katherine Macé
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-08-06     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Blood Glucose / metabolism
Decanoic Acids / therapeutic use*
Diabetes Mellitus, Type 2 / drug therapy*,  metabolism
Dicarboxylic Acids / therapeutic use*
Gluconeogenesis / physiology
Insulin Resistance
Muscle Fatigue / drug effects
Nutritive Value
Reg. No./Substance:
0/Blood Glucose; 0/Decanoic Acids; 0/Dicarboxylic Acids; 978YU42Q6I/dodecanedioic acid; 97AN39ICTC/sebacic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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