| Use of D-lactic acid measurements in the diagnosis of bacterial infections. | |
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MedLine Citation:
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PMID: 3528318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study explored the use of D-lactic acid as a marker for bacterial infections. D-Lactic was produced by frequently encountered human bacterial pathogens under anaerobic growth conditions; Bacteroides fragilis produced the largest amount. Orally administered D-lactic acid was absorbed from the intestines of rats and later found in measurable quantities in the blood and urine. Eunephric and anephric rats that received D-lactic acid intravenously showed similar quantities of this metabolite in the blood. These quantities are consistent with the distribution of D-lactic acid to total body water. Isolated liver and lung tissues from rats did not metabolize or produce D-lactic acid. Rats with experimentally induced, sublethal klebsiella peritonitis had D-lactic acidemia of 0.2 mM and 25.6 mM at 0 and 6 hr of infection, respectively. In a normal human, D-lactic acid was detected in the urine and blood after a subcutaneous injection of D-lactic acid, and pharmacokinetics of elimination similar to those of rats were found. |
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Authors:
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S M Smith; R H Eng; F Buccini |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 154 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-10-23 Completed Date: 1986-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 658-64 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobiosis Animals Bacteria / metabolism Bacterial Infections / diagnosis*, metabolism Bacteroides fragilis / metabolism Escherichia coli / metabolism Humans Kinetics Klebsiella Infections / blood Klebsiella pneumoniae / metabolism Lactates / biosynthesis, blood, metabolism* Lactic Acid Liver / metabolism Lung / metabolism Male Peritonitis / blood Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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