Document Detail

Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series.
MedLine Citation:
PMID:  20179256     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the use of lubiprostone for constipation in 3 adults with cystic fibrosis (CF).
CASE SUMMARY: This case series describes the use of lubiprostone for the treatment of constipation in 3 adults with CF (mean +/- SD length of therapy 17.3 +/- 1.5 mo). All 3 patients were prescribed lubiprostone 24 microg twice daily after hospitalization for treatment of intestinal obstruction. Patient 1 continues on chronic polyethylene glycol (PEG) 3350 and lubiprostone and has not had a recurrence of obstruction. Patient 2 requires aggressive chronic therapy with PEG 3350, lubiprostone, and methylnaltrexone. She has had 1 recurrence of obstruction. Patient 3 continues with lubiprostone taken several times per week with good control of constipation and no recurrence of obstruction to date. The adverse effect profile has been tolerable in all 3 patients.
DISCUSSION: CF is caused by a genetic mutation resulting in a dysfunctional or absent CF transmembrane conductance regulator that normally functions as a chloride channel. This results in viscous secretions in multiple organ systems including the lungs and intestinal tract. Accumulation of viscous intestinal contents contributes to constipation, which is common among adults with CF and can sometimes lead to intestinal obstruction. Lubiprostone is indicated for chronic constipation and works by activating type 2 chloride channels (ClC-2) in the intestinal tract. Because it utilizes an alternate chloride channel, lubiprostone may be especially effective for constipation in patients with CF.
CONCLUSIONS: Lubiprostone provides an additional option for the treatment of constipation in adults with CF. Its use in the CF population deserves further study.
Catherine E O'Brien; Paula J Anderson; Cindy D Stowe
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-23
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  44     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-18     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-81     Citation Subset:  IM    
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MeSH Terms
Alprostadil / adverse effects,  analogs & derivatives*,  pharmacology,  therapeutic use
Chloride Channels / drug effects,  metabolism
Constipation / drug therapy*,  etiology
Cystic Fibrosis / complications*,  genetics,  physiopathology
Cystic Fibrosis Transmembrane Conductance Regulator / genetics,  metabolism
Intestinal Obstruction / drug therapy,  etiology
Recurrence / prevention & control
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Chloride Channels; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 7662KG2R6K/lubiprostone; F5TD010360/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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