Document Detail


Use of a cardioselective beta-blocker for pediatric patients with prolonged QT syndrome.
MedLine Citation:
PMID:  20960185     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The data on the efficacy of atenolol for long-QT syndrome (LQTS) are controversial. This study aimed to evaluate the efficacy of atenolol for pediatric patients with LQTS. A retrospective observational study investigating all patients who had LQTS treated with atenolol at two institutions was performed. The study identified 57 patients (23 boys and 34 girls) with a mean QT corrected for heart rate (QTc) of 521 ± 54 ms. The mean age of these patients at diagnosis was 9 ± 6 years. Their clinical manifestations included no symptoms (n = 33, 58%), ventricular tachycardia (n = 10, 18%), syncope (n = 6, 10%), resuscitated sudden cardiac death (n = 4, 7%), atrioventricular block (n = 2, 4%), and bradycardia or presyncope (n = 2, 3%). Of the 57 patients, 13 (22%) had a family history of sudden death. The follow-up period was 5.4 ± 4.5 years. Atenolol at a mean dose of 1.4 ± 0.5 mg/kg/day was administered twice a day for all the patients. The mean maximum heart rate was 132 ± 27 bpm on Holter monitors and 155 ± 16 bpm on exercise treadmill tests, with medication doses titrated up to achieve a maximum heart rate lower than 150 bpm on both tests. During the follow-up period, one patient died (noncompliant with atenolol at the time of death), and the remaining patients had no sudden cardiac death events. Four patients (8%) had recurrent ventricular arrhythmias, three of whom received an implantable cardioverter defibrillator (all symptomatic at the time of diagnosis). For three patients (6%), it was necessary to rotate to a different beta-blocker because of side effects or inadequate heart rate control. Atenolol administered twice daily constitutes a valid and effective alternative for the treatment of pediatric patients with LQTS.
Authors:
Jose M Moltedo; Jeffrey J Kim; Richard A Friedman; Naomi J Kertesz; Bryan C Cannon
Related Documents :
1949755 - Management of malignant ventricular arrhythmias using antitachycardia devices.
19641725 - Predictive factors for an effective beta-blocker therapy in chinese patients with conge...
12135245 - Prevalence of hypotensive disorders in older patients with a pacemaker in situ who atte...
3297265 - Comparison of propafenone and disopyramide in the treatment of ventricular premature co...
10560235 - Constrictive pericarditis in patients with tuberculous pericarditis.
8205495 - Insulinoma--clinical experience in ten cases.
Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  Pediatric cardiology     Volume:  32     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Affiliation:
Section of Pediatric Cardiology, Fundacion contra las enfermedades Neurologicas de la Infancia, Buenos Aires, Argentina. jmoltedo@intramed.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of 1,2,4,6-tetra-O-galloyl-?-D-glucose from P. emblica on HBsAg and HBeAg secretion in HepG2...
Next Document:  Fontan "Ten Commandments" revisited and revised.