Document Detail


Use of Cardiac Biomarkers in Neonatology.
MedLine Citation:
PMID:  22797141     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cardiac biomarkers are used to identify cardiac disease in term and preterm infants. This review discusses natriuretic peptides and cardiac troponins. Natriuretic peptides are elevated during atrial (atrial natriuretic peptide (ANP)) or ventricular (B-type natriuretic peptide (BNP) strain. They correspond well with cardiac function and can be used to identify cardiac disease. Cardiac troponins are used to assess cardiomyocyte compromise. Affected cardiomyocytes release troponin into the bloodstream, which results in elevated cardiac troponin levels. Cardiac biomarkers are increasingly incorporated into clinical trials as indicators of myocardial strain. Furthermore cardiac biomarkers can possibly be used to guide therapy and improve outcome. The natriuretic peptides and cardiac troponins offer an additional tool to diagnose and treat neonatal disease complicated by circulatory compromise. Validation of cardiac biomarkers in a population of interest and clear reference ranges are, however, needed.
Authors:
Daniel C Vijlbrief; Manon J N L Benders; Hans Kemperman; Frank van Bel; Willem B de Vries
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-13
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht 3584 EA, The Netherlands.
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