| Use of the Brief Smell Identification Test for olfactory deficit in a Norwegian population with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 17299804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Several studies have shown that Alzheimer's disease (AD) is associated with hyposmia. Olfactory identification may be a cheap and simple additional test in the assessment of early cognitive changes. The sense of smell is influenced by factors such as experience and culture and the aim of the present study was to assess the validity of the Brief Smell Identification Test (B-SIT) in distinguishing patients with AD from healthy gender and age-matched controls in a Norwegian population. METHODS: The study included 39 patients with a diagnosis of probable AD, and 52 gender and age-matched controls. Olfactory function was assessed with B-SIT, and a non-standardized olfactory identification task (freshly ground coffee). RESULTS: The difference in olfactory performance between patients and controls was highly significant, both for the whole AD patient group and the subgroup of patients with MMSE >or= 24. Receiver operating curve (ROC) analyses indicated that B-SIT distinguished patients from controls with high sensitivity and specificity. All the odours in B-SIT with the exception of turpentine showed highly significant differences between patients and controls. AD-associated memory impairment did not seem to affect the answers given for B-SIT in this population. CONCLUSIONS: For patients with AD, the Brief Smell Identification Test (B-SIT) appears to be well-suited for detecting a deficit in olfactory identification in a Norwegian population. |
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Authors:
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Grete Kjelvik; Sigrid Botne Sando; Jan Aasly; Knut A Engedal; Linda R White |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of geriatric psychiatry Volume: 22 ISSN: 0885-6230 ISO Abbreviation: Int J Geriatr Psychiatry Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2008-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710629 Medline TA: Int J Geriatr Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 1020-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Neuroscience, Norwegian University of Technology and Science, Trondheim, Norway. kjelvik@ntnu.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / complications, physiopathology* Area Under Curve Case-Control Studies Female Humans Male Middle Aged Neuropsychological Tests Norway Olfaction Disorders / diagnosis, etiology, physiopathology* Smell / physiology* |
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