Document Detail


Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements.
MedLine Citation:
PMID:  22661464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We studied the capabilities of the Argus II retinal prosthesis for guiding fine hand movement, and demonstrated and quantified guidance improvement when using the device over when not using the device for progressively less predictable trajectories.
METHODS: A total of 21 patients with retinitis pigmentosa (RP), remaining vision no more than bare light perception, and an implanted Argus II epiretinal prostheses used a touchscreen to trace white paths on black backgrounds. Sets of paths were divided into three categories: right-angle/single-turn, mixed-angle/single-turn, and mixed-angle/two-turn. Subjects trained on paths by using prosthetic vision and auditory feedback, and then were tested without auditory feedback, with and without prosthetic vision. Custom software recorded position and timing information for any contact that subjects made with the screen. The area between the correct path and the trace, and the elapsed time to trace a path were used to evaluate subject performance.
RESULTS: For right-angle/single-turn sets, average tracing error was reduced by 63% and tracing time increased by 156% when using the prosthesis, relative to residual vision. With mixed-angle/single-turn sets, error was reduced by 53% and time to complete tracing increased by 184%. Prosthesis use decreased error by 38% and increased tracing time by 252% for paths that incorporated two turns.
CONCLUSIONS: Use of an epiretinal visual prosthesis can allow RP patients with no more than bare light perception to guide fine hand movement visually. Further, prosthetic input tends to make subjects slower when performing tracing tasks, presumably reflecting greater effort. (ClinicalTrials.gov number, NCT01123928.)
Authors:
Michael P Barry; Gislin Dagnelie;
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Publication Detail:
Type:  Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural     Date:  2012-08-01
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2012-10-09     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5095-101     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. mbarry11@jhu.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00407602
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Hand / physiology*
Humans
Movement / physiology*
Psychomotor Performance / physiology
Retina / physiology*
Retinitis Pigmentosa / physiopathology,  surgery*
Visual Perception / physiology*
Visual Prosthesis*
Grant Support
ID/Acronym/Agency:
R01 EY021220/EY/NEI NIH HHS; R01 EY021220/EY/NEI NIH HHS
Investigator
Investigator/Affiliation:
Aries Arditi / ; Rajat Agrawal / ; Pierre-Olivier Barale / ; David Birch / ; Susmito Biswas / ; Gary Brown / ; Artur V Cideciyan / ; Lyndon da Cruz / ; Gislin Dagnelie / ; Eugene de Juan / ; Lucian Del Priore / ; Jacque L Duncan / ; Dean Eliott / ; Amani Fawzi / ; Eugene Filley / ; Farhad Hafezi / ; Julia Haller / ; James Handa / ; Allen Ho / ; Mark Humayun / ; Samuel G Jacobson / ; Saddek Mohand-Said / ; Lisa Olmos / ; Marco Pelizzone / ; Angelica Perez-Fornos / ; Carl Regillo / ; Enrique Roig / ; Avinoam B Safran / ; José-Alain Sahel / ; Joel Salzmann / ; Arturo Santos / ; Sarah Sheer / ; Jörg Sommerhalder / ; Rand Spencer / ; Paulo E Stanga / ; George Turner / ; Andrew Webster /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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