Document Detail

Use of Amniostat-FLM in detecting the presence of phosphatidylglycerol in vaginal pool samples in preterm premature rupture of membranes.
MedLine Citation:
PMID:  8372866     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The presence of phosphatidylglycerol in amniotic fluid from the vaginal pool has been established as a reliable marker of pulmonary maturity in pregnancies complicated by preterm premature rupture of membranes because its presence is not affected by contaminants. This study was undertaken to determine the distribution of positive phosphatidylglycerol relative to gestational age from vaginal pool amniotic fluid samples and to assess the efficacy and accuracy of the Amniostat-FLM (Hana Biologics; Irvine Scientific after Sept. 14, 1989), an antibody agglutination method for rapidly detecting phosphatidylglycerol. STUDY DESIGN: All singleton nondiabetic pregnancies between 26 and 36 weeks with premature rupture of membranes from whom a vaginal pool sample was obtained were studied. The percent positive by gestational age was analyzed. The neonates that were delivered with a positive phosphatidylglycerol were evaluated for the presence of hyaline membrane disease and other immediate sequelae of prematurity. RESULTS: Of the 201 vaginal pool amniotic fluid samples assayed for phosphatidylglycerol with the Amniostat-FLM procedure, 18% (36/201) were positive for phosphatidylglycerol and none of the delivered infants developed hyaline membrane disease. CONCLUSION: The Amniostat-FLM seems to be accurate in predicting pulmonary maturity from vaginal pool samples.
D F Lewis; C V Towers; C A Major; T Asrat; M P Nageotte; R K Freeman; T J Garite
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, UCI Medical Center, University of California, Irvine.
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MeSH Terms
Agglutination Tests
Amniotic Fluid / chemistry*
Antibodies, Monoclonal / diagnostic use
Fetal Membranes, Premature Rupture*
Fetal Organ Maturity
Gestational Age
Lung / embryology*
Phosphatidylglycerols / analysis*
Prospective Studies
Reagent Kits, Diagnostic
Retrospective Studies
Vagina / chemistry*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Phosphatidylglycerols; 0/Reagent Kits, Diagnostic
Comment In:
Am J Obstet Gynecol. 1994 Aug;171(2):576-7   [PMID:  8059851 ]

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