Document Detail


Use of an 8(1)3(2) asymmetrical factorial design for the in vitro evaluation of ondansetron permeation through human epidermis.
MedLine Citation:
PMID:  15000465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro permeation of ondansetron through human cadaver epidermis, as a preliminary step toward the development of a transdermal therapeutic system, was investigated. In vitro release studies were carried out using modified Franz diffusion cells and human epidermis, taken from cadaver skin by heat separation technique. To estimate the effect of the type and concentration of the penetration enhancers and the skin from different donors, an 8(1)3(2) asymmetrical factorial design was used. Formulations containing lauric acid and oleic acid as penetration enhancers, showed the largest Q values [amounts of ondansetron permeated per unit area of epidermal membrane (microg/cm2)] at 24, 48, and 72 hr, as well as steady-state flux values, among all formulations tested. The other enhancers increased the flux in the following order: lauryl alcohol>glycerol monooleate>Azone >cineole>oleyl alcohol>1-methyl-2-pyrrolidinone. Moreover, the concentration of the penetration enhancer and the type of the skin were proved to significantly affect the permeation rate of ondansetron through human epidermis. From the results obtained, it was shown that the formulations containing lauric acid or oleic acid at 5% or 10% could increase sufficiently the permeation of ondansetron. Therefore, the transdermal administration of ondansetron seems feasible.
Authors:
Dimitrios A Dimas; Paraskevas P Dallas; Dimitrios M Rekkas
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  9     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-05     Completed Date:  2004-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Affiliation:
Division of Pharmaceutical Technology, School of Pharmacy, University of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Diffusion Chambers, Culture / methods
Drug Evaluation, Preclinical / methods,  statistics & numerical data*
Epidermis / metabolism*
Humans
Ondansetron / pharmacokinetics*
Permeability / drug effects
Research Design* / statistics & numerical data
Skin Absorption / physiology
Tissue Donors / statistics & numerical data
Chemical
Reg. No./Substance:
99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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