Document Detail

Use of 20% fat emulsion in total parenteral nutrition.
MedLine Citation:
PMID:  3079687     Owner:  NLM     Status:  MEDLINE    
Sixteen elderly postoperative patients were randomized in a crossover study comparing isocaloric volumes of 20% and 10% fat emulsions used for total parenteral nutrition (TPN). The caloric intake was maintained constant during the two 7-day periods of each infusion. The indices measured after each period were total volume of fluid administered, change in body weight, hematocrit, serum sodium, creatinine, albumin, blood urea nitrogen, glucose, inorganic phosphate, and cholesterol. The total volume of 10% isocaloric nutrient solution was significantly (p less than .05) greater than that of the 20% solution. A rise in body weight and a fall in serum indices of hydration status were observed; five patients developed clinical signs of overhydration while on the 10% solution. These changes did not occur with the 20% solution. Thus, isocaloric substitution of a 20% fat emulsion for a 10% fat emulsion with TPN prevented overhydration and hemodilution without compromising nutrient intake.
M M Meguid; M P Akahoshi; D Debonis; R J Hayashi; W G Hammond
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  14     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-05     Completed Date:  1986-02-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-31     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Fat Emulsions, Intravenous / therapeutic use*
Middle Aged
Neoplasms / surgery,  therapy*
Parenteral Nutrition, Total / methods*
Postoperative Period
Random Allocation
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous

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