| Use of (18F)FDG-PET in patients with suspicion of recurrent differentiated thyroid cancer by elevated antithyroglobulin antibodies levels and negative (131)I scan. | |
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MedLine Citation:
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PMID: 21334773 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To evaluate the utility of (18F)FDG-PET for patients diagnosed of differentiated thyroid carcinoma who present risk of disease and invaluable levels of thyroglobulin (Tg) by the presence of antibodies antithyroglobulin (AbTg). MATERIAL AND METHODS: Retrospective study of 7 women of 40 years old and histological diagnosis of differentiated thyroid cancer (7 papillary tumours) that were sent to our department for the accomplishment of(18F)FDG-PET study because of suspicion of disease, due to (131)I negative and high levels of AbTg, between the year 2002 and 2007. 11 PET scans were obtained after the intravenous injection of 370-434 MBq of (18F)FDG in normoglycemia conditions and previous administration of muscle relaxant, hydration and diuretic. The results of (18F)FDG-PET scans were confirmed by pathologic examination or clinical outcome and radiographic examination for more than 24 months. RESULTS: The prevalence of recurrence in our population was 57.14%. All patients presented levels of Tg lower than 3 ng/dl and AbTg superior to 200 UI/ml. Three patients had precedent thyroiditis. Out of 11 scans performed 3 of them were negative and 8 cases were found positive. It ruled out the existence of disease in three patients and localized the presence of recurrence in 4 patients. CONCLUSION: (18F)FDG-PET CONCLUSION: 18F-FDG-PET is a useful diagnostic tool for the detection of recurrence as well as to rule out the existence of disease with a high accuracy, in patients with differentiated thyroid carcinoma with (131)I whole body scan negative but with pathological elevation of antithyroglobulin antibodies. |
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Authors:
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S Sanz Viedma; I Borrego Dorado; J R Rodríguez Rodríguez; E Navarro González; R Vázquez Albertino; R Fernández López; A Agudo Martínez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-18 |
Journal Detail:
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Title: Revista espanola de medicina nuclear Volume: - ISSN: 0212-6982 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208726 Medline TA: Rev Esp Med Nucl Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier España, S.L. y SEMNIM. All rights reserved. |
Affiliation:
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Unidad de Gestión Diagnóstica de Medicina Nuclear, Hospital Universitario Virgen del Rocío, Sevilla, España. |
Vernacular Title:
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Uso de la PET-(18)F-FDG en pacientes con sospecha de recurrencia de cáncer diferenciado de tiroides por anticuerpos anti-tiroglobulina elevados y rastreo (131)I negativo. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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