| Use of 111In-labeled alginate to study the pH dependence of alginic acid anti-esophageal reflux barrier. | |
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MedLine Citation:
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PMID: 3254879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mixtures of alginic acid and antacid, when given orally, react with gastric acid to form a viscous barrier (raft) which floats on the surface of the gastric contents. 111In was used to label magnesium alginate in order to study the effect of gastric acidity on the extent of formation of the raft. In vitro, acid concentrations less than 0.05 N diminished raft formation. In vivo, raft formation was significantly better in normal subjects who ingested dilute acid with the labeled alginate/antacid than in subjects who ingested the labeled alginate/antacid with plain water. Gastric emptying of the labeled alginate was also slowed by the presence of acidified gastric contents. These results suggest that the formation of an effective alginic acid antireflux barrier requires acidic gastric contents. |
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Authors:
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L C Knight; A H Maurer; I A Ammar; J A Siegel; R S Fisher; L S Malmud |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 15 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1988 |
Date Detail:
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Created Date: 1989-09-21 Completed Date: 1989-09-21 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 563-71 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Imaging, Temple University School of Medicine, Philadelphia, PA 19140. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alginates / pharmacokinetics, therapeutic use* Aluminum Hydroxide / pharmacokinetics, therapeutic use* Animals Bicarbonates / pharmacokinetics, therapeutic use* Carbonates / pharmacokinetics, therapeutic use* Cats Gastric Acidity Determination Gastric Emptying Gastroesophageal Reflux / drug therapy* Humans Indium Radioisotopes / diagnostic use* Male Middle Aged Rats Rats, Inbred Strains Stomach / radionuclide imaging Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Bicarbonates; 0/Carbonates; 0/Indium Radioisotopes; 111565-85-6/Algicon; 21645-51-2/Aluminum Hydroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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