Document Detail


Usage of saccharin in food products and its intake by the population of Lucknow, India.
MedLine Citation:
PMID:  17118869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A survey of the usage patterns of the artificial sweetener, saccharin, in edible products and a study of its intake pattern in different population groups has been carried out. Of the different edible commodities, ice candy (87 samples) and crushed ice (14 samples), commonly consumed by children, and pan masala (16 samples) and pan flavourings (10 samples), consumed by the habitual population, were collected from different areas of Lucknow, India. Saccharin was extracted from the samples according to an AOAC method and analysed by HPLC. The consumption pattern of ice candy and crushed ice was determined for 6-20 year olds from a household dietary survey using the food frequency recall method (414 families having 1039 subjects). The consumption of pan masala and pan was assessed by a survey of habitual adult consumers comprising 782 and 1141 subjects, respectively. The average and maximum amounts of saccharin in pan masala samples were 12 750 and 24 300 mg kg-1, respectively, which are 1.6- and 3-fold higher than the maximum permitted levels allowed under Prevention of Food Adulteration (PFA) Act of India. In pan flavourings, the average and maximum amount of saccharin was 12.2 and 20.1%, i.e. 1.52- and 2.5-fold higher than the permissible limits of the PFA Act. The samples of ice candy and crushed ice showed average and maximum levels of 200 and 700 mg kg-1 and 280 and 460 mg kg-1, respectively. The average intake of saccharin through ice candy and crushed ice was less than 21% of the acceptable daily intake (ADI) (5 mg kg-1 body weight (bw) day-1). However, the maximum intake of saccharin, especially in the 6-10-year age group, contributed 57 and 68% of the ADI through ice candy and crushed ice, respectively. Maximum consumption of saccharin in all the age groups, if consuming both ice candy and crushed ice, results in exceeding the ADI by 54% for subjects in the 6-10-year age group. Hence, the 6-10-year age group population may be at risk of exceeding the ADI for saccharin. The average and maximum theoretical daily intake of saccharin through pan masala alone was 1.84 and 13.33 mg kg-1 bw day-1, contributing 37 and 267% of the ADI, whereas the estimated (maximum) daily intake was 810% of the ADI. The estimated maximum daily intake (EDI) of saccharin through pan was 6.87 mg kg-1 bw day-1, which was 137% of the ADI. Thus, individuals in the maximum consumption group for pan masala or pan may be susceptible to toxic effects of saccharin, including bladder distention, elevated urine osmolality and bladder cancer.
Authors:
Meenakshi Tripathi; Subhash K Khanna; Mukul Das
Related Documents :
20487589 - Determination of the in vivo prebiotic potential of a maize-based whole grain breakfast...
24929709 - Antifungal effect of antimicrobial peptides (amps lr14) derived from lactobacillus plan...
1512429 - Nutrient intakes and dietary patterns of older americans: a national study.
8483859 - Age, sex, educational attainment, and race/ethnicity in relation to consumption of spec...
23746329 - Consuming a low-fat diet from weaning to adulthood reverses the programming of food pre...
1314519 - Sources of fiber and fat in diets of us women aged 19 to 50: implications for nutrition...
17364149 - Modelling recolonization of second-growth forest stands by the north american red squir...
8248769 - Management methods of reducing radionuclide contamination of animal food products.
15936519 - Caloric restriction and physical activity in zebrafish (danio rerio).
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  23     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  1265-75     Citation Subset:  IM    
Affiliation:
Food Toxicology Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, , P.O. Box 80, Lucknow 226001, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Chromatography, High Pressure Liquid / methods
Diet Surveys
Food Analysis / methods
Food Habits*
Humans
India
Saccharin / administration & dosage,  analysis*
Sweetening Agents / administration & dosage,  analysis*
Chemical
Reg. No./Substance:
0/Sweetening Agents; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of hidden allergens: detection of pistachio traces in mortadella.
Next Document:  Determination of acrylamide in coffee and coffee products by GC-MS using an improved SPE clean-up.