| Usability of a microtapered needle (TN3305) for insulin treatment in japanese patients with diabetes mellitus: a comparative clinical study with a standard thin wall needle. | |
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MedLine Citation:
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PMID: 16939373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We evaluated the clinical usability of a microtapered needle (TN3305, "Needle T," Terumo Corp., Tokyo, Japan) by comparing it with a standard needle (Micro-Fine +, 31 gauge, 5 mm, thin wall, "Needle B," Nippon Becton Dickinson Co., Ltd., Tokyo) in a multicenter study. METHODS: Ninety-nine patients with diabetes mellitus being treated in 11 Japanese hospitals were enrolled in the study. Written consent was obtained from all patients. They were allocated randomly to two groups by an envelope (crossover) method. Injections were performed using one needle first, followed by the other needle 4 or 5 days later. Pain caused by injection was evaluated using a visual analogue scale (VAS). RESULTS: In the overall evaluation, Needle T was chosen by 40 patients (44.4%) and Needle B by 17 (18.8%); 33 patients (36.7%) expressed no preference. VAS scores for Needles T and B were 1.48 +/- 0.18 and 2.47 +/- 0.24 cm, respectively (P < 0.001). In this study, lower VAS indicated less pain. CONCLUSIONS: The preferences and VAS scores suggested that Needle T caused less pain than Needle B. The incidence of adverse events and safety were equivalent for both needles. We believe that usability of Needle T by patients for self-injection is better. |
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Authors:
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Toshinari Asakura; Hiroaki Seino; Kiyohide Nunoi; Kazuyo Hashimoto; Tatsuya Mutou; Katsuya Yamazaki; Minako Kakutani; Ken-Ichi Toraishi; Masafumi Kitaoka; Harumi Daikoku; Kazuhiko Sugiyama; Koushi Narasaki; Kazuo Tsuji; Shinsaku Ohnishi; Kazushige Oto; Tsutomu Tsujimoto; Reiko Nakano |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 8 ISSN: 1520-9156 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2006-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 489-94 Citation Subset: IM |
Affiliation:
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Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. asa-mac@m7.dion.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cross-Over Studies Diabetes Mellitus / drug therapy* Female Humans Injections, Intradermal / adverse effects, instrumentation* Insulin / administration & dosage* Japan Male Middle Aged Needles* Pain / etiology Pain Measurement Self Administration |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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