| Ursolic acid: a potent inhibitor of superoxides produced in the cellular system. | |
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MedLine Citation:
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PMID: 17295383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triterpenoids of ursane class: ursolic acid, ilelatifol D, corosolic acid and euscaphic acid were isolated for the first time from Leonurus cardiaca, a member of the family Lamiaceae. The isolated compounds were tested for their cell-based antiinflammatory potential by suppressing respiratory burst activity and superoxide scavenging property by using xanthine/xanthine oxidase system to produce superoxides in the cell-free system. Ursolic acid was found to be an excellent inhibitor for the superoxides produced in the cellular system, while the same was inactive in the superoxide scavenging activity in cell-free system. |
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Authors:
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Muhammad S Ali; Syed A Ibrahim; Saima Jalil; Muhammad I Choudhary |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 21 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-22 Completed Date: 2007-09-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 558-61 Citation Subset: IM |
Copyright Information:
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(c) 2007 John Wiley & Sons, Ltd. |
Affiliation:
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HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. shaiq303@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Dose-Response Relationship, Drug Free Radical Scavengers / chemistry, pharmacology* Humans Lamiaceae / chemistry Molecular Structure Neutrophils / cytology, drug effects, metabolism Respiratory Burst / drug effects* Superoxides / antagonists & inhibitors*, metabolism Triterpenes / chemistry, pharmacology* Xanthine Oxidase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Triterpenes; 11062-77-4/Superoxides; 4547-24-4/corosolic acid; 53155-25-2/euscaphic acid; 77-52-1/ursolic acid; EC 1.17.3.2/Xanthine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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