Document Detail


Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system.
MedLine Citation:
PMID:  8000393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An attempt was made to isolate the active component of Eriobotrya japonica, which inhibits aflatoxin B1-induced mutagenicity in the Salmonella assay system. The number of revertants per plate was significantly decreased when a MeOH extract of Eriobotrya japonica was added to the assay system using Salmonella typhimurium TA100 or TA98. Furthermore, we examined the effect of each fraction purified from the MeOH extract, and an EtOAc fraction was found to be the most effective. Ursolic acid isolated from the EtOAc fraction markedly and significantly decreased the numbers of Salmonella typhimurium TA100 revertants per plate, thus showing antimutagenic activity.
Authors:
H S Young; H Y Chung; C K Lee; K Y Park; T Yokozawa; H Oura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  990-2     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, Pusan National University, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1 / toxicity*
Animals
Antimutagenic Agents / pharmacology*
Male
Plant Extracts / pharmacology
Rats
Rats, Sprague-Dawley
Salmonella typhimurium / drug effects
Triterpenes / pharmacology*
Chemical
Reg. No./Substance:
0/Antimutagenic Agents; 0/Plant Extracts; 0/Triterpenes; 1162-65-8/Aflatoxin B1; 77-52-1/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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