| Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. | |
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MedLine Citation:
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PMID: 9146783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Results from animal studies and preliminary data from pilot studies in patients with primary biliary cirrhosis suggest that tauro-ursodeoxycholic acid has metabolic properties that may favour its long-term use as an alternative to ursodeoxycholic acid for patients with chronic cholestatic liver diseases. No direct comparison of tauro-ursodeoxycholic and ursodeoxycholic acids have yet been carried out in primary biliary cirrhosis. METHODS: The effects of ursodeoxycholic and tauro-ursodeoxycholic acids were compared in 23 patients with primary biliary cirrhosis according to a crossover design. Both drugs were administered at the daily dose of 500 mg. in a randomly assigned sequence for two 6-month periods separated by a 3-month wash-out period. RESULTS: Serum liver enzymes related to cholestasis and cytolysis consistently improved, as compared to baseline values, during the administration of both ursodeoxycholic and tauro-ursodeoxycholic acids, but no significant difference between these two bile acids was found. Both treatments were well tolerated and no patient complained of side effects. CONCLUSION: In the short-term, tauro-ursodeoxycholic acid appears to be safe and at least as effective as ursodeoxycholic acid for the treatment of primary biliary cirrhosis. |
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Authors:
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A Larghi; A Crosignani; P M Battezzati; G De Valle; M Allocca; P Invernizzi; M Zuin; M Podda |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 11 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-27 Completed Date: 1997-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, School of Medicine Ospedale San Paolo, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholagogues and Choleretics
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therapeutic use* Cross-Over Studies Humans Lipids / blood Liver / enzymology Liver Cirrhosis, Biliary / blood, drug therapy* Middle Aged Pilot Projects Taurochenodeoxycholic Acid / therapeutic use* Ursodeoxycholic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 0/Lipids; 128-13-2/Ursodeoxycholic Acid; 14605-22-2/tauroursodeoxycholic acid; 516-35-8/Taurochenodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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