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Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis: Long-term results.
MedLine Citation:
PMID:  22154224     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The combination of ursodeoxycholic acid (UDCA) and vitamin E is a therapeutic option for nonalcoholic steatohepatitis (NASH) but randomized controlled studies have produced inconsistent results. The objective of this study was to report the long-term tolerability and efficacy of this combination in our ten-year single center experience. METHODS: The study group included 101 adult patients with persistent elevation of serum aminotransferases (AST and ALT) and/or γ glutamyl-transferase (GGT), in whom a histological diagnosis of NASH was made from January 1998 to January 2009, and who were treated with a combination of UDCA with vitamin E. RESULTS: Median body mass index (30kg/m(2)) remained unchanged during the study. UDCA and vitamin E were well tolerated (5% withdrawal for side effects). Mean serum AST, ALT and GGT levels (expressed as times of Upper Normal Limit) diminished significantly (1.39±0.74 to 0.78±0.34 for AST, 1.72±0.92 to 0.91±0.69 for AST and 3.25±2.85 to 1.30±1.30 for GGT). AST, ALT and GGT reached normal range in 80%, 70% and 65% of the patients, respectively. From the ten patients who had a second liver biopsy during follow-up, NAS score improved in seven, and worsened in one. CONCLUSIONS: The combination of UDCA with vitamin E significantly improves liver function tests in long-term and is very well tolerated.
Authors:
Florence Pietu; Olivier Guillaud; Thomas Walter; Mélanie Vallin; Valérie Hervieu; Jean-Yves Scoazec; Jérôme Dumortier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-7
Journal Detail:
Title:  Clinics and research in hepatology and gastroenterology     Volume:  -     ISSN:  2210-741X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101553659     Medline TA:  Clin Res Hepatol Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Masson SAS.
Affiliation:
Hospices civils de Lyon pavillon H, hôpital Édouard- Herriot, fédération des spécialités digestives, 69437 Lyon cedex 03, France; Université de Lyon, université Claude-Bernard Lyon 1, domaine de la Doua, 69622 Villeurbanne, France.
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